Pangmiaomiao Zhang

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I am a Chemistry Ph.D. candidate at the University of Texas at Austin in the Lin Bio-AFM Lab, with an expected graduation date of May 2027. I develop bioanalytical assays to study nucleic acid-protein interactions and biomolecular structure. My work combines biochemical methods with high-speed atomic force microscopy (HS-AFM), mass photometry, fluorescence assays, and electron microscopy.

My current research examines G2L4 reverse transcriptase-mediated DNA repair, the effect of viral glycosylation on SARS-CoV-2 spike-antibody interactions, and the structure of the SARS-CoV-2 membrane protein. My first-author manuscript on G2L4-mediated DNA repair has been accepted in Nature Communications. I also serve as a teaching assistant and manage shared HS-AFM instrumentation in the Lin Bio-AFM Lab.

Previously, I earned an M.Sc. in Chemistry from Tsinghua University, where I developed fluorescence sensor arrays for disease-related biomolecular analysis, and a B.Sc. in Chemistry from Southern University of Science and Technology, where I studied organic synthesis and catalysis. I received the Chemistry Department Research Fellowship at UT Austin in 2026.

News

Sep 26, 2026 My first-author study on G2L4 reverse transcriptase-mediated DNA repair has been accepted in Nature Communications. The preprint is available on bioRxiv.
May 1, 2026 I received the Chemistry Department Research Fellowship at UT Austin.

Selected Publications

  1. Nat. Commun.
    Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology-Mediated End Joining
    Pangmiaomiao Zhang, Mo Guo, Y. Jessie Zhang, and 2 more authors
    Nature Communications, 2026
    Accepted manuscript; preprint posted on bioRxiv in March 2026
  2. Biophys. J.
    Real-Time Visualization of Intermolecular Interactions between SARS-CoV-2 Spike Protein and NTD-Binding Antibody Using High-Speed Atomic Force Microscopy
    Pangmiaomiao Zhang, Chia-Wei Chou, Ilya J. Finkelstein, and 1 more author
    Biophysical Journal, 2024
    Poster presentation at the Biophysical Society Annual Meeting 2024
  3. Anal. Chem.
    Cross-Reactive Fluorescent Sensor Array for Discrimination of Amyloid Beta Aggregates
    Pangmiaomiao Zhang and Chunyan Tan
    Analytical Chemistry, 2022
  4. Asian J. Org. Chem.
    Phosphine Catalyzed Enantioselective [1+4]-Annulation of Morita-Baylis-Hillman Carbonates with α,β-Unsaturated Imines
    Chenxiao Qian, Pangmiaomiao Zhang, Wenjun Li, and 1 more author
    Asian Journal of Organic Chemistry, 2019